Anemia and testosterone deficiency risk: insights from NHANES data analysis and a Mendelian randomization analysis
| Autor: | Zhenming Zheng, Jiashan Pan, Ming Liu, Zhimin Chen, Lvwen Zhang, Jingjing Gao, Pan Gao, Xiansheng Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | The Aging Male, Vol 27, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 13685538 1473-0790 1368-5538 |
| DOI: | 10.1080/13685538.2024.2346312 |
| Popis: | AbstractBackground Previous research has shown that testosterone deficiency (TD) increases the risk of anemia, but it is unclear whether anemia affects testosterone levels. This study investigated the influence of anemia on testosterone levels.Methods Utilizing data from six NHANES cycles, including demographic, testosterone levels, and hemoglobin concentrations, we employed multivariable-adjusted logistic regression to investigate the relationship between anemia and testosterone levels. Moreover, a two-sample Mendelian randomization (MR) study employing genome-wide association study (GWAS) data examined the causal relationship. Kaplan–Meier survival estimation was used to compared the overall survival (OS) of anemic and nonanemic patients with low testosterone and normal testosterone levels.Results The inclusion of 21,786 participants (2318 with anemia and19,468 without anemia) revealed that nonanemic patients exhibited higher testosterone levels than did anemic patients (β = 22.616, 95% CI: 3.873–41.359, p = 0.01807). MR analysis confirmed anemia as a cause of TD (OR = 1.045, 95% CI: 1.020–1.071, p |
| Databáze: | Directory of Open Access Journals |
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