| Autor: |
Davide Gornati, Roberta Sinisi, Stefania Bertuolo, Marilenia De Matteo, Romano Di Fabio |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Results in Chemistry, Vol 4, Iss , Pp 100654- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2211-7156 |
| DOI: |
10.1016/j.rechem.2022.100654 |
| Popis: |
An efficient synthetic route was set up to prepare in good scale M-108, a novel bicycle derivative recently identified as a potent and selective G9a inhibitor, potentially useful as anti-fibroadipogenic agent. In particular, a facile three-steps sequential transformation of a substituted cis-cinnamate ethyl ester intermediate allowed to obtain the corresponding cyclopropyl nitrile derivative in high yield, which was smoothly transformed into the title racemate and then resolved by chiral HPLC. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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