| Autor: |
Antonio Aceti, Lory Marika Margarucci, Elena Scaramucci, Massimiliano Orsini, Gerardo Salerno, Gabriele Di Sante, Gianluca Gianfranceschi, Rosa Di Liddo, Federica Valeriani, Francesco Ria, Maurizio Simmaco, Pier Paolo Parnigotto, Matteo Vitali, Vincenzo Romano Spica, Fabrizio Michetti |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-020-75618-0 |
| Popis: |
Abstract SARS-CoV-2 infection shows a wide-ranging clinical severity, requiring prognostic markers. We focused on S100B, a calcium-binding protein present in biological fluids, being a reliable biomarker in disorders having inflammatory processes as common basis and RAGE as main receptor. Since Covid-19 is characterized by a potent inflammatory response also involving RAGE, we tested if S100B serum levels were related to disease severity. Serum samples (n = 74) were collected from hospitalized SARS-CoV-2 positive patients admitted to Covid center. Illness severity was established by admission clinical criteria and Covid risk score. Treatment protocols followed WHO guidelines available at the time. Circulating S100B was determined by ELISA assay. Statistical analysis used Pearson’s χ2 test, t-Test, and ANOVA, ANCOVA, Linear Regression. S100B was detected in serum from Covid-19 patients, significantly correlating with disease severity as shown both by the level of intensity of care (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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