| Autor: |
Jie Hao, Qingyan Yan, Zhihui Li, Xiaomei Liu, Jun Peng, Tao Zhang, Jianjun Li, Dong Li, Dan He, Daijun Zhou |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Materials Today Advances, Vol 16, Iss , Pp 100317- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2590-0498 |
| DOI: |
10.1016/j.mtadv.2022.100317 |
| Popis: |
The development of radiotherapy technology improved outcomes in rectal cancer. Nevertheless, radiotherapy resistance has become a significant problem. This resistance is associated with tumor microenvironment (TME) hypoxia, cell cycle block, and related genetic alterations. We designed a novel miRNA-delivered and improved hypoxic microenvironment sensitization therapy for rectal cancer. With the protection of Zeolitic Imidazolate Framework-8 (ZIF-8) and the delivery of nano-manganese dioxide particles, the nanocomplex exhibited outstanding catalytic mimetic activity in decomposing hydrogen peroxide into oxygen, thus significantly reversing the TME hypoxia. The radiosensitizer miRNA-181a induces DNA damage directly after radiotherapy. We loaded miR181a into the MnO2@ZIF-8-polyethylene glycol nanocomplex to prevent its degradation in the circulatory system and successfully carry miR181a into the tumor. MiR181a-MnO2@ZIF-8 overcame radioresistance and enhanced therapeutic efficacy in a subcutaneous tumor model. This multiple sensitization strategy of the combined delivery of miR181a with MnO2@ZIF-8 nanoenzymes provides a promising therapeutic approach for rectal cancer. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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