Emergency surgeries for complicated colorectal cancer performed in hospitals for general surgery: multivariate analysis of short-term and long-term treatment outcomes
| Autor: | S. N. Shchaeva |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Тазовая хирургия и онкология, Vol 9, Iss 2, Pp 38-46 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2686-9594 2220-3478 |
| DOI: | 10.17650/2220-3478-2019-9-2-38-46 |
| Popis: | Objective: to evaluate the outcomes of emergency surgeries for complicated colorectal cancer performed in hospitals for general surgery and to assess risk factors and their impact on both short-term and long-term treatment outcomes.Materials and methods. This study included 677patients that underwent emergency surgeries for complicated colorectal cancer in 3 hospitals for general surgery in Smolensk over the last 13 years. Severity of postoperative complications was graded using the Clavien—Dindo classification. The length of follow-up varied between 0 and 60 months. Kaplan—Meier survival curves were constructed to assess relapse-free and overall survival. The Cox proportional regression model was used to estimate the risk factors for survival.Results. The main risk factors affecting short-term treatment outcomes were the severity of the overall condition (grave and critical) and time from symptom onset to hospital admission (>24 h). Using univariate and multivariate analysis, we identified independent prognostic factors associated with poorer 5-year relapse-free survival. They included presence of cancer cells at the resection margin (R1 resection) (hazard ratio (HR) 1.36; 95 % confidence interval (CI) 1.284—1.450; p |
| Databáze: | Directory of Open Access Journals |
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