Irreversible inhibitors of the 3C protease of Coxsackie virus through templated assembly of protein-binding fragments
| Autor: | Daniel Becker, Zuzanna Kaczmarska, Christoph Arkona, Robert Schulz, Carolin Tauber, Gerhard Wolber, Rolf Hilgenfeld, Miquel Coll, Jörg Rademann |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 94025185 |
| DOI: | 10.1038/ncomms12761 |
| Popis: | Molecular fragments are useful tools in drug-discovery but they might be hard to identify due to their weak affinity to the targets. Here, the authors use a protein-templated assembly to design high affinity inhibitors of Coxsackie virus 3C protease, a pharmacological target against enteroviral infections. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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