Protective efficacy of Capsicum frutescens fruits in pancreatic, hepatic and renal cell injury and their attenuation of oxidative stress in diabetic Wistar rats

Autor: M. R. Maya, V. Ananthi, A. Arun, P. Kumar, M. Govarthanan, K. Rameshkumar, V. Veeramanikandan, P. Balaji
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Taibah University for Science, Vol 15, Iss 1, Pp 1232-1243 (2021)
Druh dokumentu: article
ISSN: 1658-3655
16583655
DOI: 10.1080/16583655.2021.2024998
Popis: According to our insight, it is the first investigation based on a literature review to establish the oxidative stress defense and hypoglycemic effects of Capsicum frutescens fruits. The anti-hyperglycemic effect of acetone extract of the fruits of C. frutescens (CFA) was imposed at 250mg/kg and 500mg/kg for 21 days in diabetic-induced Wistar rats. The rats were divided into five groups as control, diabetic, diabetic receiving glibenclamide, and two diabetic receiving CFA-treatment groups. Beginning on the 4th day and up to the 21st day of therapy, CFA at 250mg/kg and 500mg/kg demonstrated a substantial decrease in Blood Glucose Levels (BGL). CFA at 500mg/kg led to a considerable decrease in Low-Density Lipoprotein (LDL) cholesterol and a substantial increase in High-Density Lipoprotein (HDL) cholesterol, showing that CFA possesses anti-diabetic properties. Histopathological examinations reveal hepatic, pancreatic, and renal regularization. As a result, the current study clearly demonstrated more important antidiabetic activity of CFA extracts.
Databáze: Directory of Open Access Journals
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