The Ribosome Biogenesis—Cancer Connection

Autor:	Marianna Penzo, Lorenzo Montanaro, Davide Treré, Massimo Derenzini
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	nucleolus ribosome biogenesis ribosomal proteins p53 AgNORs tumour pathology chronic inflammatory diseases ribosomopathies tumourigenesis cancer chemotherapy Cytology QH573-671
Zdroj:	Cells, Vol 8, Iss 1, p 55 (2019)
Druh dokumentu:	article
ISSN:	2073-4409
DOI:	10.3390/cells8010055
Popis:	Multifaceted relations link ribosome biogenesis to cancer. Ribosome biogenesis takes place in the nucleolus. Clarifying the mechanisms involved in this nucleolar function and its relationship with cell proliferation: 1) allowed the understanding of the reasons for the nucleolar changes in cancer cells and their exploitation in tumor pathology, 2) defined the importance of the inhibition of ribosome biogenesis in cancer chemotherapy and 3) focused the attention on alterations of ribosome biogenesis in the pathogenesis of cancer. This review summarizes the research milestones regarding these relevant relationships between ribosome biogenesis and cancer. The structure and function of the nucleolus will also be briefly described.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ac53d0f473ca4b7fb3e2f6aefc4d3afd Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.