Retinoblastoma tumor suppressor gene: An overview
| Autor: | Sunila Thomas, Anita Balan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Journal of Indian Academy of Oral Medicine and Radiology, Vol 24, Iss 1, Pp 30-35 (2012) |
| Druh dokumentu: | article |
| ISSN: | 0972-1363 0975-1572 |
| Popis: | A genetic basis for the development of cancer has been hypothesized for nearly a century and has been supported by familial, epidemiological and cytogenetic studies. Current view is that carcinogenesis is a multistep process involving activation of oncogenes or inactivation of tumor suppressor genes. Tumor suppressor gene is a gene whose protein product can inhibit the transformation of a normal cell to a tumor cell and therefore, whose loss of function can contribute to the malignant transformation of cell. The retinoblastoma gene (Rb) is the first tumor suppressor gene identified and plays a key role in the regulation of cell cycle. A diverse body of evidence now indicates that pRb stands in the midst of a regulatory pathway and suffers disruption during the pathogenesis of majority of human tumors, including oral cancers- However, recent studies point to a more general function of pRb. In addition to tumor suppression, Rb has a role in cellular differentiation and apoptosis. This review provides an insight into the complex functions of pRb with particular reference to its role in tumor suppression. |
| Databáze: | Directory of Open Access Journals |
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