Restoration of Liver Function in Cases of Surgical Obstructive Jaundice after Biliary Decompression: A Longitudinal Study
| Autor: | Udybir Singh, Sumit Chakravarti, Atul Jain, Sarika Arora, Shyam Lal, PK Patnaik |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 15, Iss 11, Pp 01-07 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2249-782X 0973-709X |
| DOI: | 10.7860/JCDR/2021/48620.15586 |
| Popis: | Introduction: Surgical Obstructive Jaundice (SOJ) is caused by obstruction of bile duct with the resultant increase in serum bilirubin level with or without pruritus, biliary colic and cholangitis. Liver Function Tests (LFTs) can help the clinician in screening patients for presence of liver disease with probable cause, its severity with prognosis assessment and also monitor efficacy of therapy. Aim: To study the liver biochemical parameters with pattern and extent of restoration in cases of SOJ (benign and malignant), before and after biliary decompression, done either by definitive surgery or endoscopic procedure. Materials and Methods: This longitudinal study was carried out from October 2014 to May 2016 in 50 patients of obstructive jaundice at ESI PGIMSR and Hospital, Basaidarapur, New Delhi, India. All patients with benign as well as malignant conditions leading to SOJ, who were amenable to endoscopic or surgical decompression were included and patients of medical jaundice were excluded. Clinical examination and blood investigations (LFT) were done preoperative, postoperative on Day 3, Day 7, Day 14 and during follow-up at 4 week, 12 week. Collection of data was done from the patients included as per criteria, data included demographical data, presenting features, aetiology and therapeutic intervention carried out obstructive jaundice (endoscopic or surgical) and the preoperative parameters and postprocedure parameters (LFT) in a sequential manner. Data analysis was carried out on Statistical Package for the Social Sciences (SPSS) version 22.0. The statistical significance of difference in values of various biochemical and clinical parameters over the study period was assessed by using one-way Analysis of Variance (ANOVA). The p-value of |
| Databáze: | Directory of Open Access Journals |
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