Evaluation of the Relationship between Pain Exposure and Somatosensory Evoked Potentials in Preterm Infants: A Prospective Cohort Study

Autor: Caterina Coviello, Silvia Lori, Giovanna Bertini, Simona Montano, Simonetta Gabbanini, Maria Bastianelli, Cesarina Cossu, Sara Cavaliere, Clara Lunardi, Carlo Dani
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Children, Vol 11, Iss 6, p 676 (2024)
Druh dokumentu: article
ISSN: 2227-9067
DOI: 10.3390/children11060676
Popis: Background and aim: First, to compare somatosensory evoked potentials (SEPs) in preterm newborns without major brain injury studied at term equivalent age (TEA) with a term historical control group. Second, to investigate the impact of pain exposure during the first 28 days after birth on SEPs. Third, to evaluate the association between SEPs and Bayley-III at 2 years corrected age (CA). Methods: Infants born at p < 0.005), adjusting for clinical risk factors. Younger GA and postmenstrual age (PMA) at SEP recording were associated with longer N1 latency and lower N1-P1 amplitude (all p < 0.005). A normal SEP at TEA positively predicted cognitive outcome at 2 years CA (p < 0.005). Conclusion: Pain exposure and prematurity were risk factors for altered SEP parameters at TEA. SEPs predicted cognitive outcome.
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