Frequent Manipulation of Resistance Training Variables Promotes Myofibrillar Spacing Changes in Resistance-Trained Individuals

Autor: Carlton D. Fox, Paulo H. C. Mesquita, Joshua S. Godwin, Vitor Angleri, Felipe Damas, Bradley A. Ruple, Casey L. Sexton, Michael D. Brown, Andreas N. Kavazis, Kaelin C. Young, Carlos Ugrinowitsch, Cleiton A. Libardi, Michael D. Roberts
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Frontiers in Physiology, Vol 12 (2021)
Druh dokumentu: article
ISSN: 1664-042X
DOI: 10.3389/fphys.2021.773995
Popis: We sought to determine if manipulating resistance training (RT) variables differentially altered the expression of select sarcoplasmic and myofibril proteins as well as myofibrillar spacing in myofibers. Resistance-trained men (n = 20; 26 ± 3 years old) trained for 8 weeks where a randomized leg performed either a standard (CON) or variable RT protocol (VAR: manipulation of load, volume, muscle action, and rest intervals at each RT session). A pre-training (PRE) vastus lateralis biopsy was obtained from a randomized single leg, and biopsies were obtained from both legs 96 h following the last training bout. The sarcoplasmic protein pool was assayed for proteins involved in energy metabolism, and the myofibril protein pool was assayed for relative myosin heavy chain (MHC) and actin protein abundances. Sections were also histologically analyzed to obtain myofibril spacing characteristics. VAR resulted in ~12% greater volume load (VL) compared to CON (p
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