| Autor: |
Wunan Zhou, Meron Teklu, Vy Bui, Grigory A. Manyak, Promita Kapoor, Amit K. Dey, Alexander V. Sorokin, Nidhi Patel, Heather L. Teague, Martin P. Playford, Julie Erb-Alvarez, Justin A. Rodante, Andrew Keel, Sujata M. Shanbhag, Li-Yueh Hsu, David A. Bluemke, Marcus Y. Chen, Marcus Carlsson, Nehal N. Mehta |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
American Journal of Preventive Cardiology, Vol 7, Iss , Pp 100211- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2666-6677 |
| DOI: |
10.1016/j.ajpc.2021.100211 |
| Popis: |
Objective: Increased left ventricular (LV) mass is an important precursor to heart failure. Inflammation plays an important role in increasing LV mass. However, the contribution of subclinical coronary artery disease (CAD) to the inflammation-LV mass relationship is unknown. In subjects with psoriasis, a chronic inflammatory skin disease, we evaluated if systemic inflammation assessed by plasma glycoprotein A (GlycA) associated with LV mass measured on coronary CT angiography (CCTA). Additionally, we analyzed whether this relationship was mediated by early CAD assessed as noncalcified coronary burden (NCB). Methods: We performed an observational longitudinal study of 213 subjects with psoriasis free of known cardiovascular disease, 189 of whom were followed over one year. All participants had GlycA measurements by nuclear magnetic resonance spectroscopy and LV mass and NCB quantified by CCTA. Results: The cohort had a mean age of 50.3 (±12.9) years and 59% were male. There was moderate psoriasis severity and low cardiovascular risk. LV mass increased by GlycA tertiles [1st tertile:24.6 g/m2.7(3.8), 2nd tertile:25.5 g/m2.7(3.8), 3rd tertile:27.7 g/m2.7(5.5), p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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