| Autor: |
Popat B. Mohite, V. H. Bhaskar |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Orbital: The Electronic Journal of Chemistry, Vol 3, Iss 2, Pp 117-124 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1984-6428 |
| DOI: |
10.17807/orbital.v3i2.225 |
| Popis: |
In attempt to find new pharmacologically active molecules, we report here the synthesis and in vitro antimicrobial activities of various novel 1,3,4-oxadiazole containing 5-phenyltetrazole. The Schiff bases were obtained by condensation 2-(5-phenyl-1H-tetrazol-1-yl)acetohydrazide with various aromatic aldehydes. Cyclocondensation of Schiff’s bases with acetic anhydride results in 1,3,4-oxadiazole derivatives. The structures of the newly synthesized 1,3,4-oxadiazole were confirmed by FT-IR, 1H NMR and mass spectral data. The antimicrobial activity was determined by MIC method. All the compounds exhibited weak to potent antimicrobial activity. Some derivatives bearing a methoxy group exhibited very good antimicrobial activity at conc. of 62.5 µg/mL. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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