Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells reported in an asymptomatic patient: a rare case and literature review

Autor: Ramen Sakhi, Ameer Hamza, Muhammad Siddique Khurram, Warda Ibrar, Paul Mazzara
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Autopsy and Case Reports, Vol 7, Iss 4 (2017)
Druh dokumentu: article
ISSN: 2236-1960
DOI: 10.4322/acr.2017.042
Popis: Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells (UC-OGC) is a rare and poorly described pancreatic malignancy. It is comprised of mononuclear, pleomorphic, and undifferentiated cells as well as osteoclast-like giant cells (OGC’s). It constitutes less than 1% of pancreatic non-endocrine neoplasia and is twice as likely to occur in females as in males. Its histopathologic properties remain poorly understood. It is suspected that UC-OGC is of epithelial origin that can then transition to mesenchymal elements. As part of this study, we describe a case of a malignant pancreatic neoplasm that was discovered in a 69-year old patient as an incidental finding. We also provide an overview of previously published data to highlight UC-OGC’s clinical and pathologic features.
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