Efficacy of vision-based treatments for children and teens with amblyopia: a systematic review and meta-analysis of randomised controlled trials

Autor: Benjamin Thompson, Mark Oremus, Taylor Adrian Brin, Amy Chow, Caitlin Carter, William Bobier
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMJ Open Ophthalmology, Vol 6, Iss 1 (2021)
Druh dokumentu: article
ISSN: 2397-3269
DOI: 10.1136/bmjophth-2020-000657
Popis: Objective To identify differences in efficacy between vision-based treatments for improving visual acuity (VA) of the amblyopic eye in persons aged 4–17 years old.Data sources Ovid Embase, PubMed (Medline), the Cochrane Library, Vision Cite and Scopus were systematically searched from 1975 to 17 June 2020.Methods Two independent reviewers screened search results for randomised controlled trials of vision-based amblyopia treatments that specified change in amblyopic eye VA (logMAR) as the primary outcome measure. Quality was assessed via risk of bias and GRADE (Grading of Recommendations, Assessment, Development, and Evaluations).Results Of the 3346 studies identified, 36 were included in a narrative synthesis. A random effects meta-analysis (five studies) compared the efficacy of binocular treatments versus patching: mean difference −0.03 logMAR; 95% CI 0.01 to 0.04 (p
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