| Autor: |
Claudia Lädrach, Martin Wartenberg, Stefan Zimmerli, Lukas Anschuetz, Stefan Bohlen, Julian Ebner, Claire M.F. de Gouyon Matignon de Pontouraude, Marco Caversaccio, Franca Wagner |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Case Reports in Neurology, Pp 1-1 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1662-680X |
| DOI: |
10.1159/000538539 |
| Popis: |
Introduction: Rhino-orbital-cerebral mucormycosis (ROCM) is a rare angioinvasive fungal infection known to be associated with high morbidity and over 50% mortality. ROCM is becoming more common due to an increase in predisposing immunocompromising comorbidities as well as COVID-19. Case Presentations: We report 2 cases – a 75-year-old woman with diabetes and a 39-year-old man with recurrent diabetic ketoacidosis. Both presented initially with acute sinonasal symptoms, were positive for SARS-CoV-2, and diagnosed with acute ROCM. Both underwent mutilating surgical therapy as well as high-dose amphotericin B treatment. With continued oral antifungal treatment, patient 1 showed stable symptoms despite radiographically increasing disease and died of urosepsis 5 months after first surgery. With posaconazole treatment, patient 2 recovered from the disease and showed no clinical sign of disease progression after 1 year. Conclusion: Despite the rarity of the disease, ROCM should be considered if the findings of clinical and radiological examination fit, so that a delay in treatment initiation can be avoided. As our both cases show, survival from ROCM is possible – albeit at a high cost. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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