Effect of preoperative jaundice on long-term prognosis of gallbladder carcinoma with radical resection

Autor: Xin-wei Yang, Jun-yi Chen, Zhi-jian Wen, Yu-long Li, Fei-yu Wang, Liang Li, Jue Yang, Ping-hua Yang, Bao-hua Zhang, Feng Shen
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: World Journal of Surgical Oncology, Vol 18, Iss 1, Pp 1-8 (2020)
Druh dokumentu: article
ISSN: 1477-7819
DOI: 10.1186/s12957-020-02015-2
Popis: Abstract Purposes This study was designed to evaluate the effect of preoperative jaundice on long-term prognosis of gallbladder carcinoma (GBC) after radical resection (R0). Methods A total of 267 GBC patients who underwent R0 resection from January 2004 to December 2014 were enrolled, including 54 patients with preoperative jaundice and 213 patients without jaundice. The clinicopathological parameters between the two groups were compared, and the correlation between preoperative jaundice and the long-term prognosis was furtherly analyzed. Results Unilateral and multivariate analyses of 267 GBC patients showed that the depth of tumor invasion (pT stage), lymphatic metastasis, and hepatic invasion were independent prognostic factors. The univariate and multivariate analysis of 54 GBC patients with preoperative jaundice showed that only pT stage was an independent factor for prognosis. Furthermore, the intraoperative blood transfusion and pT stage were significant different between long-term survival (survive for more than 3 years) and those who died within 3 years (P
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