Study into the reversal of septic shock with landiolol (beta blockade): STRESS-L Study protocol for a randomised trial

Autor: Daniel Francis McAuley, Simon Gates, Duncan Young, Nafisa Boota, Anthony C Gordon, Julian Bion, Dipesh Mistry, Ranjit Lall, Janet Lord, Gavin Perkins, Mervyn Singer, Tony Whitehouse, Scott Regan, Emma Skilton
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMJ Open, Vol 11, Iss 2 (2021)
Druh dokumentu: article
ISSN: 2044-6055
DOI: 10.1136/bmjopen-2020-043194
Popis: Introduction In 2013, a single-centre study reported the safe use of esmolol in patients with septic shock and tachycardia who required vasopressor therapy for more than 24 hours. Although not powered to detect a change in mortality, marked improvements were seen in survival (adjusted HR, 0.39; 95% CI, 0.26 to 0.59; p
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