| Autor: |
LIU Jian, LIU Wen-Bo, JI Xi-tuan, FEI Zhou, CHENG Guang |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
Chinese Journal of Traumatology, Vol 15, Iss 1, Pp 13-16 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1008-1275 |
| Popis: |
【Abstract】Objective: There are a great number of modified models based on the four-vessel occlusion (4VO) model of Pulsinelli and Brierley which has been used world-wide for brain ischemia research. However, up to now the problems of collateral circulations of 4VO and the difficulty in arranging a surgery to occlude the basilar artery in other models are not satisfactorily solved yet. In this study, an improved 4-vessel occlusion (I4VO) rat model which is easy to handle and able to decrease the effect of collateral circu-lation is reported. Methods: The common carotid arteries and the begin-ning of the subclavical arteries of rats were occluded for different time by one-stage apertura thoracis superior approach. Neurological deficit scores defined by the modi-fied Garcia scoring system and histopathological method were used to evaluate the effects of this model up to 7 days after reperfusion. Results: The neurological scores in the 15-min and 25-min groups decreased significantly at 24, 48 and 72 hours after reperfusion (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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