Gender modifies the effect of body mass index on lung function decline in mild-to-moderate COPD patients: a pooled analysis

Autor:	Wenjia Chen, Mohsen Sadatsafavi, J. Mark FitzGerald, Larry D. Lynd, Don D. Sin
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Body mass index FEV1 Lung function decline COPD Diseases of the respiratory system RC705-779
Zdroj:	Respiratory Research, Vol 22, Iss 1, Pp 1-8 (2021)
Druh dokumentu:	article
ISSN:	1465-993X
DOI:	10.1186/s12931-021-01656-5
Popis:	Abstract Background Low body weight is associated with poor prognosis in patients with chronic obstructive pulmonary disease (COPD). However, it is not known whether gender modifies this relationship. Methods We pooled data of 8686 COPD patients from 7 studies with a median length of 36-months of follow up. Using a longitudinal natural cubic spline regression model, we examined the dose–response relationship between body mass index (BMI) and the rate of decline in forced expiratory volume in one second (FEV1) in patients with GOLD 1 and 2 disease, stratified by gender and adjusted for age, smoking status, and cohort effects. Results There was an inverse linear relationship between BMI and the rate of FEV1 decline in GOLD Grades 1 and 2, which was modified by gender (p
Databáze:	Directory of Open Access Journals
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