Molecular Pathogenesis of Hodgkin Lymphoma: Past, Present, Future

Autor:	Marc Bienz, Salima Ramdani, Hans Knecht
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	classical Hodgkin lymphoma Hodgkin cells Reed–Sternberg cells genetic instability telomere dysfunction shelterin Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 21, Iss 18, p 6623 (2020)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596
DOI:	10.3390/ijms21186623
Popis:	Our understanding of the tumorigenesis of classical Hodgkin lymphoma (cHL) and the formation of Reed–Sternberg cells (RS-cells) has evolved drastically in the last decades. More recently, a better characterization of the signaling pathways and the cellular interactions at play have paved the way for new targeted therapy in the hopes of improving outcomes. However, important gaps in knowledge remain that may hold the key for significant changes of paradigm in this lymphoma. Here, we discuss the past, present, and future of cHL, and review in detail the more recent discoveries pertaining to genetic instability, anti-apoptotic signaling pathways, the tumoral microenvironment, and host-immune system evasion in cHL.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/538dc33d65e4499084a5d8e4651a7e89 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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