Acute severe renal failure in a patient receiving apixaban: a case report
| Autor: | Attilia Maria Pizzini, Chiara Fantoni, Stefania Zaccaroni, Mauro Silingardi |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Italian Journal of Medicine, Vol 18, Iss 2 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1877-9344 1877-9352 50163493 |
| DOI: | 10.4081/itjm.2024.1718 |
| Popis: | Because there is little clinical experience with apixaban in patients with severe renal impairment and non-valvular atrial fibrillation, the European Medicines Agency does not advise using it to prevent strokes in these patients. However, only a small number of pharmacokinetic and pharmacodynamic investigations showed how crucially different elimination pathways contribute to the clearance of apixaban. A 74-year-old male patient who was receiving apixaban treatment for stroke prevention in atrial fibrillation was referred to our hospital because of acute severe renal failure brought on by dehydration and abnormally elevated apixaban plasma levels. The patient was treated only with intravenous fluid therapy; serum creatinine recovered slowly over the course of six days, but plasma apixaban levels recovered quickly. No bleeding events have been recorded. Our experience demonstrates the safety profile of apixaban in cases of severe renal failure, but it also emphasizes the need for more research to confirm this evidence. |
| Databáze: | Directory of Open Access Journals |
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