| Autor: |
Jiayi Guo, Eun Ju Park, Asyraf Abbas, Hang T.L. Nguyen, Haruyuki Makio, Denise Goh, Zhen Wei Neo, Joe Poh Sheng Yeong, Chee Hian Tan, Zhiwen Joseph Lo, Peili Teo |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Next Materials, Vol 3, Iss , Pp 100088- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2949-8228 |
| DOI: |
10.1016/j.nxmate.2023.100088 |
| Popis: |
Bioactive non-woven dressings can be prepared by dip coating of non-woven cloth in solutions containing bioactive polyethylene bearing pendant arms of polyethylene (PE5000) and modified PEG3400-biomolecules including linear Arg-Gly-Asp (RGD), collagen fragment (Gly-Pro-Hyp)3, laminin-derived peptide (AGQWHRVSVRWGC) (A5G81) and hyaluronic acid (HA). Obtainment of ultimate coating concentration for each type of non-woven cloth is achieved such that the technically demanding bioactive polyethylene does not delaminate from the non-woven cloth itself but is of sufficient quantity for bioactivity. Scanning electron microscopy images show uniform polyethylene deposition on the non-woven cloth. Good water absorption and permeability allow the use of such bioactive polyethylene coated non-woven cloth as wound dressings. Material biocompatibility is demonstrated using in vitro human skin fibroblast assays. In vivo porcine full thickness excisional wound model shows PE5000-coated non-woven cloth can remarkably accelerate skin regeneration to close the wounds faster than clinical gold standard dressing. Thus, the results presented here may provide a promising guide for bioactive polyethylene-modified non-woven materials for wound dressing applications. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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