Carbon nanodots constructed by ginsenosides and their high inhibitory effect on neuroblastoma

Autor: Yingnan Jiang, Lizhi Xiao, Jifeng Wang, Tenghui Tian, Guancheng Liu, Yu Zhao, Jiajuan Guo, Wei Zhang, Jiawen Wang, Changbao Chen, Wenyi Gao, Bai Yang
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-15 (2023)
Druh dokumentu: article
ISSN: 1477-3155
DOI: 10.1186/s12951-023-02023-w
Popis: Abstract Background Neuroblastoma is one of the common extracranial tumors in children (infants to 2 years), accounting for 8 ~ 10% of all malignant tumors. Few special drugs have been used for clinical treatment currently. Results In this work, herbal extract ginsenosides were used to synthesize fluorescent ginsenosides carbon nanodots via a one-step hydrothermal method. At a low cocultured concentration (50 µg·mL− 1) of ginsenosides carbon nanodots, the inhibition rate and apoptosis rate of SH-SY5Y cells reached ~ 45.00% and ~ 59.66%. The in vivo experiments showed tumor volume and weight of mice in ginsenosides carbon nanodots group were ~ 49.81% and ~ 34.14% to mice in model group. Since ginsenosides were used as sole reactant, ginsenosides carbon nanodots showed low toxicity and good animal response. Conclusion Low-cost ginsenosides carbon nanodots as a new type of nanomedicine with good curative effect and little toxicity show application prospects for clinical treatment of neuroblastoma. It is proposed a new design for nanomedicine based on bioactive carbon nanodots, which used natural bioactive molecules as sole source.
Databáze: Directory of Open Access Journals
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