Protease inhibitors, inflammatory markers, and their association with outcome in dogs with naturally occurring acute pancreatitis

Autor: Sharon Kuzi, Michal Mazaki‐Tovi, Jan S. Suchodolski, Dar Rimer, Jonathan A. Lidbury, Joerg M. Steiner, Agostino Buono, Ran Nivy, Gilad Segev, Itamar Aroch
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Veterinary Internal Medicine, Vol 34, Iss 5, Pp 1801-1812 (2020)
Druh dokumentu: article
ISSN: 1939-1676
0891-6640
DOI: 10.1111/jvim.15895
Popis: Abstract Background Acute pancreatitis (AP) presumably is associated with pancreatic protease activation, protease inhibitor (PI) depletion, and inflammatory mediator secretion. Objectives Examine PIs and inflammatory mediator concentrations in dogs with AP and their association with death. Animals Thirty‐one dogs diagnosed with AP based on clinical signs, ultrasonographic findings, and increased canine pancreatic lipase immunoreactivity (cPLI) and 51 healthy control dogs. Methods Antithrombin and α2‐antiplasmin activity (ATA and α2AP, respectively) and concentrations of α1‐proteinase inhibitor (α1PI), α2‐macroglobulin (α2MG), C‐reactive protein (CRP), interleukins (ILs)‐2,6,8 and tumor necrosis factor‐α (TNF‐α) were prospectively measured. Severity of AP was assessed by clinical severity scoring systems. Results Mortality rate was 19%. Antithrombin activity was lower (P = .004) and maximal CRP, IL‐6, and TNF‐α concentrations higher (P
Databáze: Directory of Open Access Journals
Externí odkaz: