Prognosis value of microscopic bile duct invasion in hepatocellular carcinoma: A multicenter study

Autor: Qizhen Huang, Kongying Lin, Zhipeng Lin, Hongbin Ji, Xiaoyu Zhou, Bin Wang, Yufeng Chen, Chuandong Sun, Shuguo Zheng, Jinhong Chen, Yifan Wang, Yanming Zhou, Weiping Zhou, Yongyi Zeng
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Cancer Medicine, Vol 12, Iss 22, Pp 20821-20829 (2023)
Druh dokumentu: article
ISSN: 2045-7634
DOI: 10.1002/cam4.6650
Popis: Abstract Objective To evaluate the prognostic significance of microscopic bile duct invasion (MiBDI) in hepatocellular carcinoma (HCC) following R0 resection. Patients and Methods Patients who underwent R0 resection for HCC at nine medical centers were stratified into five groups: neither bile duct nor vascular invasion (MiBDI−MVI−), microscopic bile duct invasion alone (MiBDI+MVI−), both microscopic bile duct and vascular invasion (MiBDI+MVI+), microscopic vascular invasion alone (MiBDI−MVI+), and macroscopic bile duct invasion (MaBDI). Overall survival (OS) was assessed using Kaplan–Meier analysis, and independent risk factors of OS were determined using Cox proportional hazards models. Results A total of 377 HCC cases were analyzed. The OS for MiBDI+MVI‐ was similar to that of MiBDI−MVI− (p > 0.05) but better than MiBDI+MVI+, MiBDI−MVI+, and MaBDI (all p
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