| Autor: |
Joseph D. Robinson, Roscoe O. Brady, Charles R. Maxwell |
| Jazyk: |
angličtina |
| Rok vydání: |
1962 |
| Předmět: |
|
| Zdroj: |
Journal of Lipid Research, Vol 3, Iss 2, Pp 243-245 (1962) |
| Druh dokumentu: |
article |
| ISSN: |
0022-2275 |
| DOI: |
10.1016/S0022-2275(20)40435-3 |
| Popis: |
An enzyme preparation obtained from brain tissue catalyzes the stereospecific reduction of crotonyl CoA to butyrate. Tritium from TPNH3 was localized predominantly on the β-carbon of recovered butyric acid. Both this enzyme and a preparation from adipose tissue, which also catalyzes the reduction of crotonyl CoA, catalyze the synthesis of long-chain fatty acids from malonyl CoA and acetyl CoA. The significance of these findings is considered in view of the demonstration that, in long-chain fatty acids synthesized in the presence of TPNH3, labeled hydrogen is localized on alternate carbon atoms beginning with the β-carbon. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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