Mitochondrial and Lipid Droplet Dynamics Regulate Intra- and Intercellular Fatty Acid Trafficking

Autor: Sarah Cohen, Angelika S. Rambold, Jennifer Lippincott-Schwartz
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Molecular & Cellular Oncology, Vol 5, Iss 5 (2018)
Druh dokumentu: article
ISSN: 2372-3556
23723556
DOI: 10.1080/23723556.2015.1043038
Popis: Imaging of fatty acid (FA) trafficking revealed that FAs stored in lipid droplets were delivered to mitochondria when the cells were starved. This delivery required cytoplasmic lipases and mitochondrial fusion activity, whereas lipid droplets were replenished with FAs supplied by autophagy. These findings have important implications for cancer.
Databáze: Directory of Open Access Journals
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