A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy

Autor: Yue Hua, Yuan Wang, Xue Kang, Fan Xu, Zhen Han, Chong Zhang, Zhao-Yang Wang, Jun-Qi Liu, Xueli Zhao, Xiaoyuan Chen, Shuang-Quan Zang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-14 (2021)
Druh dokumentu: article
ISSN: 1477-3155
DOI: 10.1186/s12951-021-01191-x
Popis: Abstract Background As cancer is one of the main leading causes of mortality, a series of monotherapies such as chemotherapy, gene therapy and radiotherapy have been developed to overcome this thorny problem. However, a single treatment approach could not achieve satisfactory effect in many experimental explorations. Results In this study, we report the fabrication of cyclic RGD peptide (cRGD) modified Au4-iron oxide nanoparticle (Au4-IO NP-cRGD) based on aggregation-induced emission (AIE) as a multifunctional theranostic system. Besides Au4 cluster-based fluorescence imaging and enhanced radiotherapy, iron oxide (IO) nanocluster could realize magnetic resonance (MR) imaging and Fenton reaction-based chemotherapy. Abundant toxic reactive oxygen species generated from X-ray irradiation and in situ tumor-specific Fenton reaction under acidic microenvironment leads to the apoptotic and necrotic death of cancer cells. In vivo studies demonstrated good biocompatibility of Au4-IO NP-cRGD and a high tumor suppression rate of 81.1% in the synergistic therapy group. Conclusions The successful dual-modal imaging and combined tumor therapy demonstrated AIE as a promising strategy for constructing multifunctional cancer theranostic platform. Graphical Abstract
Databáze: Directory of Open Access Journals
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