Screening and surveillance of hepatocellular carcinoma by serum des‐gamma‐carboxy prothrombin in patients with glycogen storage disease type Ia

Autor:	A. B. Schreuder, R. J. Overduin, N. C. Peltenburg, L. deBoer, F. A. J. A. Bodewes, T. G. J. Derks
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	des‐gamma‐carboxy prothrombin glycogen storage disease type I hepatocellular adenoma hepatocellular carcinoma tumor markers Diseases of the endocrine glands. Clinical endocrinology RC648-665 Genetics QH426-470
Zdroj:	JIMD Reports, Vol 65, Iss 4, Pp 207-211 (2024)
Druh dokumentu:	article
ISSN:	2192-8312
DOI:	10.1002/jmd2.12414
Popis:	Abstract No sensitive tumor marker for hepatocellular carcinoma (HCC) is available for patients with glycogen storage disease type Ia (GSDIa), in whom alpha‐fetoprotein and carcino‐embryonic antigen levels often remain normal. We describe increased levels of the HCC tumor marker des‐gamma‐carboxy prothrombin (DCP) in GSDIa patients with HCC. In one case DCP levels normalized after liver transplantation. We recommend including DCP as a screening HCC tumor marker in the surveillance of patients with GSDIa.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/534a6df4145347ed9b2dd884e10ee631 Zobrazit plný text záznamu Plný text View record in DOAJ