A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate

Autor: Yi Zhang, Kunhua Li, Guang Yang, Joshua L. McBride, Steven D. Bruner, Yousong Ding
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-018-04154-3
Popis: Microviridins belong to the family of ribosomally synthesized and post-translationally modified peptides (RiPPs). Here, the authors discover a microviridin-synthesizing enzyme in a cyanobacterium that modifies multiple core peptides from a single substrate in a distributive and unstrictly directional manner, an unusual biosynthetic logic for RiPPs.
Databáze: Directory of Open Access Journals