Inspiratory fraction as a marker of skeletal muscle dysfunction in patients with COPD

Autor: P. Cebollero, F. Zambom-Ferraresi, M. Hernández, J. Hueto, J. Cascante, M.M. Anton
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Revista Portuguesa de Pneumologia (English Edition), Vol 23, Iss 1, Pp 3-9 (2017)
Druh dokumentu: article
ISSN: 2173-5115
DOI: 10.1016/j.rppnen.2016.07.003
Popis: Background: An inspiratory capacity to total lung capacity (IC/TLC) ratio of â¤25% has emerged as a better marker of mortality in chronic obstructive pulmonary disease (COPD) patients. The relationship among the IC/TLC ratio to lower extremity skeletal muscle function remains unknown. Methods: Thirty-five men with moderate to severe COPD were divided into those with IC/TLC â¤Â 25% (n = 16) and >25% (n = 19). The subjects were tested for thigh muscle mass volume (MMT), maximal strength, power output of the lower extremities, and physical activity. Results: Total MMT in the IC/TLC  25% group (575.20 ± 11.76 cm3). In the IC/TLC â¤Â 25% group, maximal strength of the lower extremities and muscle peak power output of the lower extremities were 36â56% lower (p  25% group. Conclusion: IC/TLC â¤Â 25% is associated with reduced maximal strength and peak power output of the lower extremities. IC/TLC â¤Â 25% may have an important clinical relevance as an index to determine peripheral muscle dysfunction. Keywords: Chronic obstructive pulmonary disease, Inspiratory fraction, Muscle mass, Muscle strength, Limb muscle dysfunction, Muscle power
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