Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy

Autor:	Prathyusha Konda, Liubov M. Lifshits, John A. Roque, Houston D. Cole, Colin G. Cameron, Sherri A. McFarland, Shashi Gujar
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	photosensitizer photodynamic therapy immunogenic cell death antitumor immunity Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	OncoImmunology, Vol 10, Iss 1 (2021)
Druh dokumentu:	article
ISSN:	2162-402X 2162402X
DOI:	10.1080/2162402X.2020.1863626
Popis:	We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/cd53397beefa46e8a7d7ee5b20571408 Zobrazit plný text záznamu View record in DOAJ