A study of pathological characteristics and BRAF V600E status in Langerhans cell histiocytosis of Vietnamese children
| Autor: | Thu Dang Anh Phan, Bao Gia Phung, Tu Thanh Duong, Vu Anh Hoang, Dat Quoc Ngo, Nguyen Dinh The Trinh, Tung Thanh Tran |
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| Jazyk: | English<br />Korean |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Journal of Pathology and Translational Medicine, Vol 55, Iss 2, Pp 112-117 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2383-7837 2383-7845 |
| DOI: | 10.4132/jptm.2020.11.30 |
| Popis: | Background Langerhans cell histiocytosis (LCH) is more common in children than adults and involves many organs. In children, the BRAF V600E mutation is associated with recurrent and high-risk LCH. Methods We collected paraffin blocks of 94 pediatric LCH patients to detect BRAF_V600E mutation by sequencing. The relationship between BRAF V600E status and clinicopathological parameters were also critically analyzed. Results BRAF V600E mutation exon 15 was detected in 45 cases (47.9%). Multiple systems LCH showed a significantly higher BRAF_V600E mutation rate than a single system (p=.001). No statistical significance was evident for other clinical characteristics such as age, sex, location, risk organs involvement, and CD1a expression. Conclusions In Vietnamese LCH children, the proportion of BRAF V600E mutational status was relatively high and related to multiple systems. |
| Databáze: | Directory of Open Access Journals |
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