Case report: Monoclonal antibodies as an alternative treatment for new daily persistent headache
| Autor: | Ernesto M Bancalari, Natalia Hernández, Analia Soria, Osvaldo Bruera |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Cephalalgia Reports, Vol 6 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2515-8163 25158163 |
| DOI: | 10.1177/25158163231195769 |
| Popis: | Background: New Daily Persistent Headache (NDPH) is a disabling daily headache that causes huge frustration for patients and headache specialists. Elevated TNF-alpha levels, that elevate CGRP levels, on the CSF of NDPH patients has been described as a possible cause of this disease. TNF-alpha inhibitors like doxycycline, venlafaxine, montelukast and lithium have been used in the past to treat NDPH patients, with relatively good success as described from case reports. Conclusion: We report three NDPH patients that improved with the administration of Anti CGRP monoclonal antibodies (mAbs), after trying multiple treatments. We propose this class of drugs, as a therapeutic option for NDPH. |
| Databáze: | Directory of Open Access Journals |
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