| Autor: |
Myron M Levine, ProfMD, Dilruba Nasrin, PhD, Sozinho Acácio, MD, Quique Bassat, ProfMD, Helen Powell, PhD, Sharon M Tennant, PhD, Samba O Sow, ProfMD, Dipika Sur, MD, Anita K M Zaidi, ProfMBBS, Abu S G Faruque, MD, M Jahangir Hossain, MBBS, Pedro L Alonso, ProfMD, Robert F Breiman, ProfMD, Ciara E O'Reilly, PhD, Eric D Mintz, MD, Richard Omore, PhD, John B Ochieng, MSc, Joseph O Oundo, PhD, Boubou Tamboura, PharmD, Doh Sanogo, MD, Uma Onwuchekwa, MS, Byomkesh Manna, PhD, Thandavarayan Ramamurthy, PhD, Suman Kanungo, MBBS, Shahnawaz Ahmed, MBBS, Shahida Qureshi, MSc, Farheen Quadri, MBBS, Anowar Hossain, MD, Sumon K Das, MBBS, Martin Antonio, PhD, Debasish Saha, MBBS, Inacio Mandomando, PhD, William C Blackwelder, ProfPhD, Tamer Farag, PhD, Yukun Wu, PhD, Eric R Houpt, ProfMD, Jaco J Verweiij, PhD, Halvor Sommerfelt, ProfPhD, James P Nataro, ProfMD, Roy M Robins-Browne, ProfPhD, Karen L Kotloff, ProfMD |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
The Lancet Global Health, Vol 8, Iss 2, Pp e204-e214 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2214-109X |
| DOI: |
10.1016/S2214-109X(19)30541-8 |
| Popis: |
Summary: Background: The Global Enteric Multicenter Study (GEMS) was a 3-year case-control study that measured the burden, aetiology, and consequences of moderate-to-severe diarrhoea (MSD) in children aged 0–59 months. GEMS-1A, a 12-month follow-on study, comprised two parallel case-control studies, one assessing MSD and the other less-severe diarrhoea (LSD). In this report, we analyse the risk of death with each diarrhoea type and the specific pathogens associated with fatal outcomes. Methods: GEMS was a prospective, age-stratified, matched case-control study done at seven sites in Africa and Asia. Children aged 0–59 months with MSD seeking care at sentinel health centres were recruited along with one to three randomly selected matched community control children without diarrhoea. In the 12-month GEMS-1A follow-on study, children with LSD and matched controls, in addition to children with MSD and matched controls, were recruited at six of the seven sites; only cases of MSD and controls were enrolled at the seventh site. We compared risk of death during the period between enrolment and one follow-up household visit done about 60 days later (range 50–90 days) in children with MSD and LSD and in their respective controls. Approximately 50 pathogens were detected using, as appropriate, classic bacteriology, immunoassays, gel-based PCR and reverse transcriptase PCR, and quantitative real-time PCR (qPCR). Specimens from a subset of GEMS cases and controls were also tested by a TaqMan Array Card that compartmentalised probe-based qPCR for 32 enteropathogens. Findings: 223 (2·0%) of 11 108 children with MSD and 43 (0·3%) of 16 369 matched controls died between study enrolment and the follow-up visit at about 60 days (hazard ratio [HR] 8·16, 95% CI 5·69–11·68, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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