Диагностика синдрома активации макрофагов в зависимости от исходного уровня IL-6 у пациентов с новой коронавирусной инфекцией, вызванной вирусом SARS-CoV-2
| Autor: | Alexander F. Popov, E. V. Markelova, I. A. Komarova, A. V. Kostiushko, M. Yu. Shchelkanov |
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| Jazyk: | ruština |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Инфекция и иммунитет, Vol 12, Iss 4, Pp 668-676 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2220-7619 2313-7398 |
| DOI: | 10.15789/2220-7619-AEO-1673 |
| Popis: | An effect of the antiviral drug Kagocel on the levels of metalloproteinases MMP-8 and MMP-9 and their tissue inhibitors TIMP-1 and TIMP-2 in induced sputum during treatment of community-acquired viral-bacterial pneumonia was analyzed. 60 adult patients with verified community-acquired pneumonia of viral-bacterial etiology were included in the follow-up monitoring. Materials and methods. All patients were randomly stratified into 2 groups: group 1 (comparison group) consisted of 30 patients receiving Ceftriaxone monotherapy; group 2 (main group) 30 subjects who were prescribed Ceftriaxone and the antiviral drug Kagocel as etiotropic treatment. Both groups were comparable in gender, age and time of admission to the hospital. Results. During hospitalization, patients in both groups had elevated levels of MMP-8, MMP-9, TIMP-1 and TIMP-2 in induced sputum compared to the reference values. By 7 days of inpatient treatment, the level of MMP-8 was still significantly higher than the reference values in both groups, being in patients from group 2 it decreased compared to baseline values, whereas in patients from group 1, on the contrary, it was markedly elevated. The activity of MMP-9 during hospitalization was also high in patients from both groups compared with its level in healthy subjects. By day 7 of therapy, changes in various parameters were recorded. The level of MMP-9 in patients from group 1 increased, whereas in group 2 on the contrary decreased. The level of TIMP-1 decreased in patients of the 1st group below the control value, and in patients of the 2nd group reached the reference values. The level of TIMP-2 decreased in both groups and reached that of in control group. Conclusion. Antiviral drug Kagocel being included in the standard antibacterial regimen of community-acquired viral-bacterial pneumonia reduces the level of MMR-9 and intensity in imbalance between MMP and TIMP parameters by 7 days of therapy, which leads to accelerated clinical recovery. |
| Databáze: | Directory of Open Access Journals |
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