Autor: |
Søren R. Paludan, Jesper Melchjorsen, Sampsa Matikainen |
Jazyk: |
angličtina |
Rok vydání: |
2009 |
Předmět: |
|
Zdroj: |
Viruses, Vol 1, Iss 3, Pp 737-759 (2009) |
Druh dokumentu: |
article |
ISSN: |
1999-4915 |
DOI: |
10.3390/v1030737 |
Popis: |
Herpes simplex virus (HSV), a human pathogenic virus, has evolved several strategies to evade the production and function of interferons (IFNs) and cytokines generated by the innate immune system to restrict the virus. Equilibrium exists between the virus and the immune response, and a shift in this delicate balance either restricts the virus or enhances virus spread and tissue damage. Therefore, understanding of the cytokine response generated after HSV infection and the underlying virus-cell interactions is essential to improve our understanding of viral pathogenesis. This review summarizes the current knowledge on induction and evasion of the innate immune response by HSV. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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