Metal-Free Catalyzed Oxidation/Decarboxylative [3+2] Cycloaddition Sequences of 3-Formylchromones to Access Pyrroles with Anti-Cancer Activity

Autor:	Xue Li, Xing-Yu Chen, Bing-Ying Fan, Qun Yu, Jie Lei, Zhi-Gang Xu, Zhong-Zhu Chen
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	metal-free decarboxylation 3-formylchromones pyrroles anti-cancer activity Organic chemistry QD241-441
Zdroj:	Molecules, Vol 28, Iss 22, p 7602 (2023)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules28227602
Popis:	An efficient and direct approach to pyrroles was successfully developed by employing 3-formylchromones as decarboxylative coupling partners, and facilitated by microwave irradiation. The protocol utilizes easily accessible feedstocks, a catalytic amount of DBU without any metals, resulting in high efficiency and regioselectivity. Notably, all synthesized products were evaluated against five different cancer cell lines and compound 3l selectively inhibited the proliferation of HCT116 cells with an IC50 value of 10.65 μM.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/52c73cc3149146adac425bab85e8daa1 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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