| Autor: |
Ka Lai Yip, Chi Man Koon, Zi Yi Chen, Ping Chook, Ping Chung Leung, Steven Schachter, Wai Hong Leung, Chung Tong Mok, Howan Leung |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Epilepsia Open, Vol 5, Iss 1, Pp 50-60 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2470-9239 |
| DOI: |
10.1002/epi4.12372 |
| Popis: |
Abstract Objective To investigate the effect of water extract of Gastrodiae Rhizoma (GR) on the development of acquired temporal lobe epilepsy (TLE) and on regulating the expression of the mammalian target of rapamycin (mTOR) and semaphorin 3F (SEMA3F). Methods A pilocarpine‐induced status epilepticus (SE) model was adopted to precipitate injury in the limbic systems. GR and carbamazepine (CBZ) treatments were given to mice for 14 days prior to SE induction to demonstrate the antiepileptic effects and continued for 5 more days to illustrate the effects on histologic studies. Results Our results consolidated that GR treatment (92.1 minutes) could delay the SE onset in comparison with the control group (61.5 minutes, P = .041). Fewer mice had reached SE with GR treatment (41.7%) when compared with the control group (83.3%, P = .044). GR treatment (2.1 hours/mouse) could suppress the number of acute seizures in post‐SE survival mice when compared with the control group (4.5 hours/mouse, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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