Shared immune metabolic reprogramming between COVID-19 patients in the intensive care unit and ischemic stroke: a pilot study
| Autor: | Jie Li, Fushen Li, Bin He, Cong Yu, Ping Zheng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Archives of Medical Science, Vol 19, Iss 6, Pp 1904-1908 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1734-1922 1896-9151 |
| DOI: | 10.5114/aoms/172161 |
| Popis: | Introduction To investigate shared gene signatures between COVID-19 and ischemic stroke. Material and methods Combining the existing bulk RNA sequencing and single-cell RNA sequencing (scRNA-seq) data for COVID-19 to obtain a more comprehensive understanding of the role of dysregulated metabolism. Results A total of 19 up-regulated differentially expressed genes (DEGs) and 24 down-regulated genes were selected for subsequent analyses. Nine genes were finally identified with the machine learning method as a potential diagnostic model in both ischemic stroke and COVID-19. In addition, the hub genes were related to both immune infiltration and metabolic pathways. Conclusions Our study revealed the common molecular profile of COVID-19 and ischemic stroke. |
| Databáze: | Directory of Open Access Journals |
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