Immune Tolerance Induction (ITI) with a pdFVIII/VWF Concentrate (octanate) in 100 Patients in the Observational ITI (ObsITI) Study

Autor: Carmen Escuriola Ettingshausen, Vladimír Vdovin, Nadezhda Zozulya, Pavel Svirin, Tatiana Andreeva, Majda Benedik-Dolničar, Victor Jiménez-Yuste, Lidija Kitanovski, Silva Zupancic-Šalek, Anna Pavlova, Angelika Bátorová, Cesar Montaño Mejía, Gulnara Abdilova, Sigurd Knaub, Martina Jansen, Shannely Lowndes, Larisa Belyanskaya, Olaf Walter, Johannes Oldenburg
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: TH Open, Vol 06, Iss 02, Pp e124-e134 (2022)
Druh dokumentu: article
ISSN: 2512-9465
DOI: 10.1055/s-0042-1748756
Popis: Background Immune tolerance induction (ITI) with repeated factor VIII (FVIII) administration is the only strategy proven to eradicate inhibitors. The observational ITI study is evaluating ITI with a range of FVIII products. Methods This subgroup analysis reports prospective interim data for patients treated with a plasma-derived, von Willebrand factor-stabilized FVIII concentrate (pdFVIII/VWF, octanate). Complete success (CS) of ITI required achievement of three criteria: inhibitor titer
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