Supplementary prenatal copper increases plasma triiodothyronine and brown adipose tissue uncoupling protein-1 gene expression but depresses thermogenesis in newborn lambs

Autor:	Stephen B. Smith, Craig R. Sweatt, Gordon E. Carstens
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	brown adipose tissue copper lambs thermogenesis uncoupling protein-1 Animal culture SF1-1100 Animal biochemistry QP501-801
Zdroj:	Asian-Australasian Journal of Animal Sciences, Vol 33, Iss 3, Pp 506-514 (2020)
Druh dokumentu:	article
ISSN:	1011-2367 1976-5517
DOI:	10.5713/ajas.18.0179
Popis:	Objective We tested the hypothesis that increasing dietary copper (Cu) to gravid ewes would enhance brown adipose tissue (BAT) thermogenesis in their offspring. Methods Twin-bearing ewes were assigned on d 70 of gestation to diets containing 3, 10, or 20 ppm dietary Cu (n = 8 per group). Twin lambs were assigned at birth to a cold (6°C) or warm (28°C) environmental chamber for 48 h. Blood was collected from ewes and from lambs and perirenal BAT was collected after 48 h in the environmental chambers. Results Prenatal Cu exposure increased ewe plasma triiodothyronine (T3) and thyroxine concentration (T4) (p
Databáze:	Directory of Open Access Journals
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