Supplementary prenatal copper increases plasma triiodothyronine and brown adipose tissue uncoupling protein-1 gene expression but depresses thermogenesis in newborn lambs
Autor: | Stephen B. Smith, Craig R. Sweatt, Gordon E. Carstens |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: | |
Zdroj: | Asian-Australasian Journal of Animal Sciences, Vol 33, Iss 3, Pp 506-514 (2020) |
Druh dokumentu: | article |
ISSN: | 1011-2367 1976-5517 |
DOI: | 10.5713/ajas.18.0179 |
Popis: | Objective We tested the hypothesis that increasing dietary copper (Cu) to gravid ewes would enhance brown adipose tissue (BAT) thermogenesis in their offspring. Methods Twin-bearing ewes were assigned on d 70 of gestation to diets containing 3, 10, or 20 ppm dietary Cu (n = 8 per group). Twin lambs were assigned at birth to a cold (6°C) or warm (28°C) environmental chamber for 48 h. Blood was collected from ewes and from lambs and perirenal BAT was collected after 48 h in the environmental chambers. Results Prenatal Cu exposure increased ewe plasma triiodothyronine (T3) and thyroxine concentration (T4) (p |
Databáze: | Directory of Open Access Journals |
Externí odkaz: |