| Autor: |
Mariana Araújo-Pereira, Betânia M.F. Nogueira, Renata Spener-Gomes, Anna C.C. Carvalho, Flávia Marinho Sant’Anna, Marina C. Figueiredo, Megan M. Turner, Afrânio L. Kritski, Marcelo Cordeiro-Santos, Valeria C. Rolla, Timothy R. Sterling, Bruno B. Andrade, Alice M.S. Andrade, Vanessa Nascimento, Juan Manuel Cubillos-Angulo, Hayna Malta-Santos, Jéssica Rebouças-Silva, Saulo R.N. Santos, André Ramos, Pedro Brito, Carolina A.S. Schmaltz, Alysson G. Costa, Leandro Sousa Garcia, Brenda K. de Sousa Carvalho, Bruna P. de Loiola, Adriano Gomes-Silva, Francine P. Ignácio, Maria C. Lourenço, Elisangela C. Silva, Mayla Mello, Alexandra B. Souza, Beatriz Barreto-Duarte, Michael S. Rocha, Aline Benjamin, Adriana S.R. Moreira, Jamile G. de Oliveira, Solange Cavalcante, Betina Durovni, José R. Lapa-e-Silva |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Journal of Infection and Public Health, Vol 16, Iss 6, Pp 974-980 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1876-0341 |
| DOI: |
10.1016/j.jiph.2023.04.009 |
| Popis: |
Background: Tuberculosis (TB) remains a major plague of humanity. People with TB (PWTB) are commonly anemic. Here, we assessed whether the severity of anemia in PWTB prior to anti-TB treatment (ATT) was a risk factor for an unfavorable outcome. Methods: Patients ≥ 18 years old with culture-confirmed drug-susceptible pulmonary TB enrolled between 2015 and 2019 in a multi-center Brazilian cohort were followed for up to 24 months and classified according to anemia severity (mild, moderate, and severe), based on hemoglobin levels. A multinomial logistic regression model was employed to assess whether anemia was associated with unfavorable outcome (death, failure, loss to follow-up, regimen modification or relapse), compared to treatment success (cure or treatment completion). Results: Among 786 participants who met inclusion criteria, 441 (56 %) were anemic at baseline. Patients with moderate/severe anemia were more HIV-seropositive, as well as more symptomatic and had higher frequencies of unfavorable outcomes compared to the other groups. Moderate/severe anemia (adjusted OR [aOR]: 7.80, 95 %CI:1.34–45.4, p = 0.022) was associated with death independent of sex, age, BMI, HIV and glycemic status. Conclusion: Moderate/severe anemia prior to ATT was a significant risk factor for death. Such patients should be closely monitored given the high risk of unfavorable ATT outcomes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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