Concomitant diagnosis of endometrial and breast cancer - does the sequence matters?

Autor: Tomer Stern, Shira Peleg Hasson, Akram Saad, Keren Levanon, Nadav Michaan, Ido Laskov, Ido Wolf, Dan Grisaru, Tamar Safra
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Gynecologic Oncology Reports, Vol 38, Iss , Pp 100863- (2021)
Druh dokumentu: article
ISSN: 2352-5789
DOI: 10.1016/j.gore.2021.100863
Popis: Objective: To examine whether patients with both breast cancer (BC) and endometrial cancer (EC) have different features of disease, and whether the sequence of appearance of these tumors is correlated with a more aggressive course. Methods: A retrospective, multi-center observational cohort study of patients treated in two tertiary medical centers between 2014 and 2020. Files of patients who had a co-diagnosis of BC and EC were reviewed and clinical, epidemiological, pathological and genetic characteristics were collected. Results: 67 patients with a co-diagnosis of both malignances were divided into two groups according to primary tumor diagnosis: BC first group (43/67, 64%) and EC first group (24/67, 36%). The time interval between diagnosis of malignancies was significantly longer in the BC first group (mean 144.5 months vs. 67 months, p
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