Reductive Cleavage of 2,2,2-Trichloroethyl Esters by Titanocene Catalysis

Autor:	Andreas Gansäuer, Tobias Dahmen
Jazyk:	German<br />English<br />French
Rok vydání:	2012
Předmět:	Catalysis Protecting groups Radicals Synthesis Titanocenes Chemistry QD1-999
Zdroj:	CHIMIA, Vol 66, Iss 6 (2012)
Druh dokumentu:	article
ISSN:	0009-4293 2673-2424
DOI:	10.2533/chimia.2012.433
Popis:	Esters are of widespread use for protecting carboxylic acids in organic synthesis. However, methods to cleave esters often employ harsh conditions. Herein, we report a new and mild method for the reductive cleavage of 2,2,2-trichloroethylesters (TCE esters). Our radical method employs Cp2TiCl as an electron transfer catalyst and Zn dust as stoichiometric reducing agent. It avoids the use of strong Brønstedt-acids as well as aqueous conditions and can be carried out at room temperature.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/52842595c59946d69004612a38023782 Zobrazit plný text záznamu View record in DOAJ