Invasive Fungal Infections in Children with Leukemia: Clinical Features and Prognosis

Autor: Melike Sezgin Evim, Özlem Tüfekçi, Birol Baytan, Hale Ören, Solmaz Celebi, Beyza Ener, Kevser Üstün Elmas, Şebnem Yılmaz, Melek Erdem, Mustafa Kemal Hacımustafaoğlu, Adalet Meral Güneş
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Turkish Journal of Hematology, Vol 39, Iss 2, Pp 94-102 (2022)
Druh dokumentu: article
ISSN: 1308-5263
DOI: 10.4274/tjh.galenos.2021.2021.0203
Popis: Objective: The incidence of invasive fungal infections (IFIs) has increased due to intensive chemotherapy in childhood leukemia. The aim of this study was to evaluate the incidence, risk factors, causative pathogens, and impact on survival of IFIs among pediatric leukemia patients. Materials and Methods: The hospital records of 307 children with acute lymphoblastic leukemia (ALL, n=238), acute myeloid leukemia (AML, n=51), and relapsed leukemia (n=18) between January 2010 and December 2015 were retrospectively evaluated. Results: A total of 1213 febrile neutropenia episodes were recorded and 127 (10.4%) of them were related to an IFI. Of 307 children, 121 (39.4%) developed IFIs. The mean age was significantly older in the IFI group compared to children without IFIs (p
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