| Autor: |
Rui-Xia Zhu, Lei Zhao, Yu-Kun Zhang, Peng Luo, Si-Hai Liu, Jin-Guang Wang |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Bangladesh Journal of Pharmacology, Vol 10, Iss 1 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
1991-0088 |
| DOI: |
10.3329/bjp.v10i1.21641 |
| Popis: |
Combination therapy has prolonged the survival of patients with small cell lung cancer (SCLC), an aggressive neoplasm characterized by a high rate of metastasis. In the present study the effect of sequential treatment of ursolic acid chlorophenyl triazole (UACT) followed by 5-fluorouracil (5-FU) on human small cell lung cancer cells was investigated. The results revealed a synergistic effect of the sequential treatment with UACT and 5-FUcombination on cytotoxic activities, NF-kB protein activation, repression of TNF-induced NF-kB-dependent reporter gene expression, and TNF-induced COX-2, MMP-9 and Cyclin D1 activation in H209 cells. The synergism in apoptotic cell death was observed in H209, H69, 87-5,and Lu135 cells. The synergistic effect of UACT and 5-FU was observed at a concentration of 50 nM of UACT and 20 µM of 5-FU. These results indicate that UACT and 5-FU combination can be a promising chemotherapeutic regimen in the treatment of SCLC. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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