Gut-muscle axis mechanism of exercise prevention of sarcopenia

Autor: Tao Li, Danyang Yin, Rengfei Shi
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Nutrition, Vol 11 (2024)
Druh dokumentu: article
ISSN: 2296-861X
DOI: 10.3389/fnut.2024.1418778
Popis: Sarcopenia refers to an age-related systemic skeletal muscle disorder, which is characterized by loss of muscle mass and weakening of muscle strength. Gut microbiota can affect skeletal muscle through a variety of mechanisms. Gut microbiota present distinct features among elderly people and sarcopenia patients, including a decrease in microbial diversity, which might be associated with the quality and function of the skeletal muscle. There might be a gut-muscle axis; where gut microbiota and skeletal muscle may affect each other bi-directionally. Skeletal muscle can affect the biodiversity of the gut microbiota, and the latter can, in turn, affect the anabolism of skeletal muscle. This review examines recent studies exploring the relationship between gut microbiota and skeletal muscle, summarizes the effects of exercise on gut microbiota, and discusses the possible mechanisms of the gut-muscle axis.
Databáze: Directory of Open Access Journals